Ghost is a blogging platform written in nodejs.
Edit the config.js file at the ghost root directory

mail: {
   from: 'from@email.com',
   transport: 'SMTP',
   options: {
     host: "your-amazon-host",
     port: 465,
     service: "SES",
     auth: {
       user: "your-amazon-user",
       pass: "your-amazon-password"
     }
   }
}

Amazon SES credential can be generated from amazon control panel.
From address must be registered and verified as sender.

Related
Mail configuration on a self hosted ghost
Mail github source